I'm learning about when to use Calcitriol ... here's my research .. source: http://www.medsafe.govt.nz/profs/datasheet/c/CalcitriolTevacap.pdf Following multiple-dose administration, serum Calcitriol levels reached steady-state within 7 days. Distribution Calcitriol is approximately 99.9% bound in blood. Calcitriol and other vitamin D metabolites are transported in blood, by an alpha-globulin vitamin D binding protein. There is evidence that maternal Calcitriol may enter the fetal circulation. Calcitriol is transferred into human milk at low levels (i.e., 2.2 ± 0.1 pg/mL). Calcitriol is several times more potent than D3 for absorbing calcium, and calcium is the problem, not the D. The last thing people with high calcitriol levels need is more calcium absorption. Interesting Calcitriol discussion [link] ..more to come.