Nevermind Monoclonal TNF-alpha blockers use Zyban ! (aka Bupropion)

heh.

A really nice anxious/depressed crohn's patient whom has had bad disease for "20 years" said he's never been this good for his bowels ... ever. He said it started right after I put him on Bupropion. He did some research because he said, the there had to be some explanation.

He found this article.

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W7N-4J43GR8-1&_user=10&_coverDate=06%2F30%2F2006&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ffaea2e644d5a0bcaa0af02626162ee7

A new chapter opens in anti-inflammatory treatments:The antidepressant
bupropion lowers production of tumor necrosis factor-alpha and
interferon-gamma in mice

Re: Nevermind TNF-alpha blockers use Zyban !

Added to wikipedia for fun.

Surely some TNF alpha Pharma lamer will delete it.

Re: Nevermind TNF-alpha blockers use Zyban !

Per year it is about $35,000 USD less than Remicade.

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My edits are still up !

http://en.wikipedia.org/wiki/TNF_inhibitor

Re: Nevermind TNF-alpha blockers use Zyban !

http://www.modernmedicine.com/modernmedicine/Primary+Care+Medicine/ADA-2009-Weight-loss-combination-shows-efficacy-in/ArticleStandard/Article/detail/602084?contextCategoryId=40137&srcemalert=40137

A combination of naltrexone and bupropion produces a significant, 4.7% greater weight loss than placebo when combined with behavior modification, according to phase 3 study results presented by Thomas Wadden, MD, director, Center for Weight and Eating Disorders, University of Pennsylvania, Philadelphia. "This is the first phase 3 trial to evaluate the safety and efficacy of naltrexone-bupropion for body weight loss in obese patients," he reports.<p style="color: #000000; font-size: 12px; font-family: helvetica, arial, sans-serif; text-align: left">Overall, patients taking the combination lost an average of 20.3 to 25.0 pounds over 56 weeks, amounting to a loss of 9.3% to 11.5% of body weight. Patients taking placebo lost 11.0 to 16.0 pounds, for a loss of 5.1% to 7.3% of body weight. "The combination produces weight loss in the same neighborhood as orlistat and sibutramine," says Dr. Wadden.

Re: Nevermind TNF-alpha blockers use Zyban !

I had a patient lose 30lbs on Bupropion. She was a new patient, I asked her why she took Bupropion and she said it helped her lose weight.

Re: Nevermind TNF-alpha blockers use Zyban !

http://www.pslgroup.com/dg/23E1E6.htm

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What can't this stuff do ?

Re: Nevermind TNF-alpha blockers use Zyban !

Possible uses of Bupropion's Anti-Tumor Necrosis Factor - Alpha effect:


Moderate to Severe Rheumatoid Arthritis (RA)

Moderate to Severe Polyarticular Juvenile Idiopathic Arthritis (JIA)

Psoriatic Arthritis,

plaque psoriasis (PSO)

Ankylosing Spondylitis (AS)

Inflammatory Bowel Disease - adult Crohn's disease, pediatric Crohn's disease, ulcerative colitis (UC)




Others ?

Refractory Asthma

hidradenitis suppurativa

Vitiligo Improvement in a Patient with Ankylosing Spondylitis Treated with Infliximab


Monoclonal Antibody TNF-alpha inhibitors -


* Adalimumab (Humira)

* Certolizumab pegol (Cimzia)

* Etanercept (Enbrel)

* Golimumab (Simponi)

* Infliximab (Remicade)

Re: Nevermind TNF-alpha blockers use Zyban !

I wonder if the Remicade side effects are from it's TNF-alpha effects or some other reason ? What do you think Graham ?

Re: Nevermind TNF-alpha blockers use Zyban !

Use of anti-tumor necrosis factor agents: A possible therapy for vitiligo


Exciting because there are no great treatments with for Vitiligo except Topical Steroids.

Seems Bupropion is listed as a potential cure for Vitiligo

Re: Nevermind TNF-alpha blockers use Zyban !

I'll bite ...

Atopic Eczema

Re: Nevermind TNF-alpha blockers use Zyban !

>There are reports of serious infections caused by viruses, fungi or bacteria that have spread throughout the body, including tuberculosis (TB) and histoplasmosis. Some of these infections have been >fatal. Your doctor should monitor you closely for signs and symptoms of TB during treatment with REMICADE.&reg; You should discuss any concerns about your health and medical care with your doctor.

Sure ... these are common to all anti-TNF drugs.

Less of a problem with Rituximab.

Re: Nevermind TNF-alpha blockers use Zyban !

Well why wouldn't a drug like Bupropion, which may have anti-TNF-alpha effects, not have the side effects ? Is there something independent of Monoclonal Antibodies' anti-TNF-alpha effects that might cause the predisposition to infections ?

Re: Nevermind TNF-alpha blockers use Zyban !

the degree of blockade

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Definitely.

I guess I was hoping Bupropion could have as good blockage. []

Did you read that PSL article.

14 to 2 ? Must be a typo ..... probably 14 to 200 ?

Re: Nevermind TNF-alpha blockers use Zyban !

The original ScienceDirect article said "Profound Lowering".

Profound is a powerful word ! I interpreted profound as ++++

[]

Received 20 December 2005;
accepted 21 December 2005.
Available online 25 January 2006.

Abstract

In a wide range of human diseases of inflammatory nature like Crohn's disease, pathology is mediated in part by pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF) or interferon-gamma. We show here that a commonly used generic antidepressant bupropion, in wide use worldwide to treat depression in humans for a decade now, <u>profoundly</u> lowers levels of TNF, interferon-gamma, and interleukin-1 beta in vivo, in a mouse lipopolysaccharide (LPS) induced inflammation model. Mice challenged with an otherwise lethal dose of LPS were protected by bupropion and levels of the anti-inflammatory cytokine interleukin-10 were increased. Previous data in rodents and humans indicate antidepressant effects of bupropion are mediated by its weak reuptake inhibition of norepinephrine and dopamine. Concordant with this, TNF suppression by bupropion in our mouse LPS model was largely abrogated by beta-adrenergic or dopamine D1 receptor antagonists but not by a D2 antagonist. TNF synthesis is controlled by an inverse relationship with intracellular cyclic adenosine monophosphate (cAMP) and stimulation of either beta-adrenoreceptors or D1 dopaminergic receptors result in increased cAMP but stimulation of D2 receptors lowers cAMP. We conclude that bupropion may suppress TNF synthesis by mediating increased signaling at beta-adrenoreceptors and D1 receptors, resulting in increased cAMP that inhibits TNF synthesis. Bupropion is well tolerated also in non-psychiatric populations and has less risk with long term use than current anti-inflammatory, immunosuppressive or TNF suppressive treatments such as prednisone, azathioprine, infliximab, or methotrexate. New anti-inflammatory treatments are needed. We believe a new chapter in antiinflammatory, TNF lowering treatment of disease has been opened. Bupropion's use for this in humans should be explored.

Keywords: Bupropion; Crohn's disease; Dopamine; Inflammation; Interferon-gamma; Norepinephrine; Tumor necrosis factor-alpha

Re: Nevermind TNF-alpha blockers use Zyban !

A recently updated alert


Simponi (golimumab)

Audience: Rheumatological healthcare professionals

[Posted 05/27/2009] Centocor Ortho Biotech and FDA reminded healthcare professionals of the risk of serious fungal infections associated with TNF-? blockers, including Simponi [golimumab]. FDA has reported that histoplasmosis and other invasive fungal infections are not consistently recognized in patients taking other TNF-? blockers including Cimzia (certolizumab pegol), Enbrel (etanercept), Humira (adalimumab), and Remicade (infliximab). This has resulted in delays in appropriate antifungal treatment, sometimes even resulting in death. It is important that all adverse events potentially associated with Simponi be reported so that the adverse event profile reported in the prescribing information can be updated appropriately as post-approval experience is gathered. Centocor encourages reporting adverse events to Centocor at 1-800-457-6399 or to the FDA MedWatch program at 1-800-332-1088.

Re: Nevermind TNF-alpha blockers use Zyban !

http://clinicaltrials.gov/ct2/show/NCT00126373

study completed in 2006 ... no results

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I saw that as well.


Let's do some <u>Pharma Math</u>.

Should we pay off a researcher whom proves that 75% of the IBD patients can get good results with a drug that costs a dollar a day to help sell our drugs that costs $35,000 ?


Hmmmm.....

I am betting the results will be a long time coming.



Study done by


Altschuler, Eric, M.D.
GlaxoSmithKline

Dr. Altschuler is an inventor listed on a patent application for use of bupropion as a TNF-lowering agent, filed by the University of California. He is also an advisor to GlaxoSmithKline.

Hush money ?

Here he is. I emailed him.